The original scene that the image comes from takes place in American Psyco, released on April 14th, 2000. In one of the scenes, Bateman uses an axe to kill one of his victims, which is where the still used in the meme comes from (shown below).
Although the exact first meme using the scene is unknown, a reverse image search on TinEye, shows that it first appeared online February 5th, 2008, on the site Taringa but has since been deleted. In memes, the earliest known variant that still exists online was posted in a Fark thread by user drjekel_mrhyde on August 10th, 2009, in the form of a Demotivational Poster (shown below).
… Continue Reading at: knowyourmeme.com [source]